Finance Report:
Book:
Intelligent Investor, Millionaire Next Door, Common Stocks Uncommon Profits,
Charles Schwab Guide to Financial Independence, Automatic Millionaire, Zero to One, Rich Dad Poor Dad, Does your bag have holes?, Your money your life, Common Sense Investing, $100 Startup, The success principles, The five rules of successful stock investing, Total money makeover, Think and grow rich
Think and Grow Rich
The author suggests the following 4 steps:
Develop a definite purpose, backed by a burning desire for its fulfillment.
Build a definite plan, expressed in continuous action.
Keep out all negative and discouraging influences.
Stay accountable to people who will encourage you to follow through your plan and purpose.
13 Principles
Principle 1: Desire.
Principle 2: Faith.
Principle 3: Auto Suggestion.
Principle 4: Specialized Knowledge.
Principle 5: Imagination.
Principle 6: Organized Planning.
Principle 7: Decision.
Principle 8: Persistence.
Principle 9: The Power of the Mastermind
Principle 10: Transmutation
Principle 11: The Subconscious Mind
Principle 12: The Power of the Brain
Principle 13: The Sixth Sense
Set your mind on a definite goal and observe how quickly the world stands aside to let you pass.
Napoleon Hill
You can be anything you want to be, if only you believe with sufficient conviction and act accordance with your faith; for whatever the mind can conceive and believe, the mind can achieve.
Napoleon Hill
Book: Zero to One
The actual truth is that there are many more answers left to find, but they will yield only to relentless searchers. There is more to do in science, medicine, engineering, and in technology of all kinds. We are within reach not just marginal goals set at competitive edge of today’s conventional disciplines, but of ambitions so great that even the boldest minds of the Scientific Revolution hesitated to announce them directly. We could cure cancer, dementia, and all the diseases of age and metabolic decay. We can find new ways to generate energy that free the world from conflict of fossil fuels. We can invent faster ways to travel from place to place over the surface of the planet. We can even learn how to escape it entirely and settle new frontiers.
DNA, RNA, Proteins
DNA Sequencing - PacBio DNA sequence machine
Metagraph - MetaGraph compresses and indexes these gargantuan public datasets, allowing researchers to plug in a DNA sequence and instantly track where else it exists in nature
AlphaGenome - 9 billion dna mutations. Designed to solve sequence interpretation. While MetaGraph tells you where a sequence is, AlphaGenome tells you what it does. It is a foundational machine learning model trained to look at a DNA sequence and forecast complex molecular processes—such as how much RNA it will produce, where it will splice, and how proteins will bind to it.
Prime editing is a "search-and-replace" genome-editing technology developed in 2019 by Dr. David Liu's laboratory that allows for targeted insertions, deletions, and all 12 types of base-to-base conversions without creating double-strand DNA breaks.
Evo 2: A monumental genomic foundation model trained on over 9.3 trillion nucleotides across 128,000+ species. It functions at single-nucleotide resolution to read, predict, and generate genetic sequences from scratch, effectively mapping the evolutionary language of DNA and RNA.
RNA
CRISPR, TIGR, and VIPR represent distinct generations and lineages of RNA-guided genetic systems that are reshaping the landscape of biotechnology and genome engineering. While CRISPR remains the gold standard, the discovery of TIGR and VIPR introduces smaller, more flexible, and evolutionary ancient alternatives that bypass some of CRISPR's strict biological limitations.
1. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)
The Baseline: Discovered as an adaptive immune system in bacteria, CRISPR uses a continuous single-guide RNA to match an invader's DNA "mugshot" and cut it.
The Limitations: CRISPR proteins (like Cas9) are very large, making them hard to package into the viral vectors used in gene therapies. Furthermore, they require a specific neighboring DNA motif called a PAM sequence to function, restricting where they can edit.
2. TIGR (Tandem Interspaced Guide RNA)The Next Generation: Discovered by Feng Zhang’s lab at MIT/Broad Institute, TIGR-Tas systems function completely independently of traditional CRISPR pathways.
Why It's Different: Instead of reading one strand of DNA, its tigRNA uses a dual-guide system to latch onto both strands of the double helix simultaneously.
The Advantage: TIGR does not require a PAM sequence, meaning it can theoretically be programmed to target any site across a genome. Because the associated Tas proteins are incredibly compact, engineered variants like TIGRa fit easily inside standard therapeutic delivery vehicles.
3. VIPR (Viral Interference Programmable Repeat)The Ancient Progenitor: Discovered by Jennifer Doudna’s lab at UC Berkeley, VIPR is an ultra-ancient system (potentially 4+ billion years old) found inside viruses. It rewrites the history of CRISPR, suggesting bacteria actually "stole" the foundation of their immune system from viruses.
Why It's Different: VIPR completely breaks the rules of continuous genetic reading. It uses a gapped, noncontiguous code—its guide RNA reads two letters, skips one, and reads the next two. Structurally, it doesn't pry DNA apart; it forms a geometric triplex by snaking entirely around the outside of the helix.
The Advantage: The "skip-one" rule allows it to successfully bind to target viral sequences even if the target mutates its "wobble" positions. It is the smallest RNA-guided system ever discovered, making it an extraordinary candidate for minimal-footprint gene silencing, epigenetic modification, and DNA imaging.
Proteins
AlphaFold3 - 200 million proteins
AlphaProteo - designed to create novel, high-strength protein binders.
IsoDDE - Hailed as an "AlphaFold 4–level" breakthrough, this highly powerful, proprietary diffusion model generates drug molecules with near-perfect binding accuracy. It operates completely closed-source, drastically outperforming legacy physics-based simulation methods by accurately predicting drug-protein binding and antibody interactions without needing experimental crystal structures.
“Rich Dad, Poor Dad,” by Robert Kiyosaki
Key takeaway: Know the difference between an asset and a liability.
There’s a reason the rich get richer: They understand the vital yet often misunderstood difference between assets and liabilities. An asset puts money in your pocket. A liability takes money out of your pocket. In order to get rich, you must buy assets and leverage the income generated from them to buy luxuries and fund your lifestyle.
Markets: Dow, SP 500, NASDAQ
https://www.visualcapitalist.com/100-trillion-global-economy/
https://www.visualcapitalist.com/3d-map-the-u-s-cities-with-the-highest-economic-output/
America’s Natural Resources
Coal
The 249.4 billion tons of recoverable coal in America is worth roughly $30.5 trillion
Natural Gas
At current market prices, 583.9 trillion cubic feet (Tcf) of natural gas is worth roughly $1.28 trillion to $1.75 trillion.
Lithium
1.5 trillion worth of lithium in McDermott Caldera.
Oil
Green River Formation contains 3 trillion barrels of oil. 3 trillion barrels of oil in America near Utah, Wyoming, Colorado. Three trillion barrels of crude oil are worth between $261 trillion and $282 trillion.
Diamonds
Global production of gem-quality lab-grown diamonds is estimated to exceed 30 to 40 million carats annually as the industry scales rapidly, far surpassing historical levels of around 7 to 10 million carats. The global market value for lab-grown diamonds was valued at roughly $29.46 billion, and by volume, lab-grown stones now account for over 60% of all engagement ring sales in major markets like the United States. Diamond market is poised for explosive growth, projected to surge from $27.7 billion in 2025 to a staggering $44.5 billion by 2032.
Gold
Global Markets and Reserves: Most mined gold was exported to international bullion markets, such as London, to back global currencies and support the gold standard during the 19th and 20th centuries.
Total gold holdings are valued at roughly $4.6 trillion, compared to $3.9 trillion in U.S. Treasuries.
This chart shows the official gold reserves by country and the numbers are surprising.
US has 8,133 tonnes—by far the leader. Then comes Germany (3,350 tonnes), Italy (2,452 tonnes), France (2,437 tonnes), Russia (2,330 tonnes), China (2,299 tonnes) and Switzerland (1,040 tonnes).
India ranks number one in private and citizen ownership, with households and temples estimated to hold over 25,000 tonnes.
Ocean gold: While the oceans contain an estimated 20 million tons of gold, worth over $900 trillion at current prices, up to 2 quadrillion.
Space: the final frontier. These are the voyages of the starship Enterprise. Its five-year mission: to explore strange new worlds, to seek out new life and new civilizations, to boldly go where no man has gone before.
Lunar supply: Helium-3 is deposited on the Moon by solar winds. The lunar regolith is rich with it because the Moon has no protective atmosphere or magnetic field. Some estimates place the total lunar supply at $1.5 quadrillion.
Moon mining machine: Interlune unveils helium-3 harvester prototype. The machine is designed to churn up 110 tons (100 metric tons) of lunar dirt, or regolith, per hour to harvest helium-3, a potential fuel source for future fusion reactors. Helium-3 is rare on Earth but is thought to be plentiful on the moon.
Solar Jet Sparks 200,000x Surge in Rare Helium-3, mind-blowing 200,000-fold increase in a rare helium isotope, 3He – far surpassing anything ever recorded. The NASA/ESA Solar Orbiter recently detected the highest concentration ever recorded of a rare helium isotope known as helium-3 (3He), emitted from the Sun on April 2025.
While major, record-setting events (such as one with 180,000 times normal concentration) are rare, smaller jet-driven injections happen regularly.
Recurrence: These events can be highly recurrent, sometimes occurring multiple times in a few days (e.g., in March 2022).
Source: The events typically originate in active regions (plages) or at the edges of coronal holes.
Asteroid gold and metals: Asteroids contain precious metals like gold, platinum, and cobalt, with some estimates placing the value of a single metallic asteroid like 16 Psyche in the quintillions of dollars.
Asteroid 3554 Amun, a metallic asteroid, as potentially having $20 trillion in gold beneath its surface, along with another $8 trillion in iron and nickel, $6 trillion in cobalt and $6 trillion in platinum.
A Nearby Asteroid 1986 DA Contains More Than $11 Trillion in Precious Metals. More than the Earth’s entire global metal reserves. Asteroid 1986 DA, also known as (6178) 1986 DA, has a minimum distance from Earth of approximately 0.1922 AU (astronomical units), which translates to roughly 28.8 million kilometers (17.9 million miles) at its closest approach; this means it never actually crosses Earth's orbit but comes close to it from the outside. A typical spacecraft might travel at speeds around 25,000 miles per hour, which would take roughly a month to cover 28 million miles.
Asteroid 2016 ED85 and Earth varies, but it's typically less than 20 million miles from Earth every 20–30 years. 2016 ED85 is a metal-rich "mini-Psyche" asteroid. Asteroid 2016 ED85, along with asteroid 1986 DA, is estimated to contain precious metals worth $11.65 trillion.
Mars Glaciers Have More Water Content than Previously Thought. But after 20 years of exhaustive research, scientists have concluded that glaciers all over the planet contain more than 80% water ice, meaning they are nearly pure. These findings could alter our understanding of Mars' climate history and have significant implications for future crewed missions dependent on in-situ resource utilization (ISRU). Aside from providing crews with a local source of drinking water, this ice can be fashioned into oxygen gas and rocket propellant.
6000 exoplanets discovered in 2025.
The largest known water reservoir in space contains approximately 140 trillion times the water on Earth and is located around a quasar called APM 08279+5255, more than 12 billion light-years away.